A bad cough: Delayed cutaneous hypersensitivity caused by pholcodine

Effect of fluoropyrimidines on delayed cutaneous hypersensitivity.

although recently paradoxical potentiation of antibody titers has been reported (11, 14). Cancer chemotherapists have been concerned for many years that the drugs used in treating cancer might suppress any host immunity to the tumor and actually hasten rather than retard its spread. It was for this reason that the present study was under taken. Briefly, the experimental design consisted of asse...

Sorafenib Induces Delayed-Onset Cutaneous Hypersensitivity: A Case Series

Sorafenib is an oral multikinase inhibitor with clinical activity against hepatocellular carcinoma (HCC) and renal cell carcinoma. Administration of sorafenib carries a variety of adverse cutaneous reactions. Common adverse effects induced by sorafenib include hand-foot skin reactions, facial erythema, splinter subungual hemorrhage, and alopecia. Although erythema multiforme (EM) related to sor...

Immune cell populations in cutaneous delayed-type hypersensitivity

Delayed-type hypersensitivity (DTH) is a prototypic T lymphocyte-mediated response to antigenic challenge. In this study, mononuclear cells infiltrating the skin during cutaneous response to tuberculin in presensitized human subjects (responders) and nonimmune controls were identified using monoclonal antibodies by indirect immunofluorescence. In both responders and controls the infiltrate cons...

Delayed cutaneous hypersensitivity to oxazolone in mice with tumors.

A murine model of immune responsiveness had been adapted to study anergic conditions associated with neoplasia. Marked anergy observed in mice bearing L1210 leukemia and P-388 lymphoma is contrasted to the minimal immune depression associated with B-16 melanotic melanoma and Sarcoma 180J. The ability of N,N-bis(2-chloroethyl)-N-nitrosourea chemotherapy to reduce tumor burden without prolonged s...

Antigenic Properties of Human Tumours: Delayed Cutaneous Hypersensitivity Reactions.